Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells
نویسندگان
چکیده
منابع مشابه
Embryonic Stem Cells/induced Pluripotent Stem Cells
Understanding the regulation of cell-cell interactions during the formation of compact myocardial structures is important for achieving true cardiac regeneration through enhancing the integration of stem cell-derived cardiomyocytes into the recipient myocardium. In this study, we found that cellular repressor of E1A-stimulated genes 1 (CREG1) is highly expressed in both embryonic and adult hear...
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Successful isolation, derivation and culturing of human pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced pluripotent stem (hiPSCs) cells in laboratory scale has opened new horizones for cell therapy applications such as tissue engineering and regenerative medicine. However, most of the cell therapy protocols using these unique cells require large number of ...
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We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the efficiency of induced pluripotent stem (iPS) cell derivation from human adult or fetal fibroblasts. After transient butyrate treatment, the iPS cell derivation efficiency is enhanced by 15to 51-fold using either retroviral or piggyBac transposo...
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Early in 1981, the pluripotential cells were first established from mouse embryos by Evans et al (Evans and Kaufman, 1981). In the same year, Martin et al (Martin, 1981) named these pluripotential cells embryonic stem (ES) cells. In 1990s, human ES cells were first established by Thomson et al (Thomson et al., 1998). Such ES cells isolated from inner cell masses of blastocysts present the uniqu...
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Cultured pluripotent stem cells hold great promise for regenerative medicine. Considerable efforts have been invested into the refinement and definition of improved culture systems that sustain self-renewal and avoid differentiation of pluripotent cells in vitro. Recent studies have, however, found that the choice of culture condition has a significant impact on epigenetic profiles of cultured ...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature08534